This comprehensive panel evaluates intestinal permeability, immune reactivity to wheat/gluten proteins, and cross-reactivity to gluten-associated foods. It aids in identifying leaky gut syndrome, gluten-related autoimmunity, and sensitivities to foods that may mimic gluten. Targets: Array 2: Tight junction proteins (occludin, zonulin), actomyosin, lipopolysaccharides (LPS). Array 3X: Wheat and gluten proteins, including gliadin, glutenin, gluteomorphin, and transglutaminases. Array 4: Cross-reactive foods such as dairy proteins (casein, butyrophilin), oats, corn, rice, millet, yeast, and others. Method/Analytes Measured: Enzyme-Linked Immunosorbent Assay (ELISA) detecting IgG and IgA antibodies. Clinical Use: Identifies increased intestinal permeability ("leaky gut"). Detects immune responses to wheat/gluten proteins, aiding in the diagnosis of celiac disease and non-celiac gluten sensitivity. Uncovers sensitivities to foods that may cross-react with gluten, which is crucial for patients not responding to a gluten-free diet. Assists in developing personalized dietary interventions to manage autoimmune and inflammatory conditions.