What is it?

The Anti-HEV IgM (Quantitative) test detects and measures the level of IgM antibodies against the Hepatitis E Virus (HEV) in the blood. These IgM antibodies are produced by the immune system shortly after exposure to the virus, making this test useful for diagnosing recent or acute Hepatitis E infections.

Why is the Test Done?

1. To Diagnose Acute Hepatitis E:
2. If you have symptoms of hepatitis (e.g., yellowing of the skin/eyes, dark urine, abdominal pain, nausea), this test confirms if the cause is an active HEV infection.
3. To Detect Recent Exposure to HEV:
4. IgM antibodies typically appear early in the infection and remain detectable for a short period (weeks to a few months).
5. For Specific Populations:
6. It’s particularly critical for:

• Pregnant women, as Hepatitis E can cause severe complications.
• People with weakened immune systems.
• Travelers returning from areas where Hepatitis E is common (e.g., developing countries with poor sanitation).

When is it Needed?

• If you have symptoms of hepatitis, such as:
• Fatigue, fever, nausea, and vomiting.
• Jaundice (yellow skin/eyes).
• Abdominal pain or discomfort.
• Dark-colored urine and pale stools.
• If you've recently traveled to regions with outbreaks or poor sanitation.
• If there’s an unexplained rise in liver enzymes (ALT/AST).

Understanding Results:

1. Positive Anti-HEV IgM:

• Indicates a recent or ongoing Hepatitis E infection.
• May require further evaluation for liver damage or complications, especially in high-risk groups.

1. Negative Anti-HEV IgM:

• No evidence of recent or acute infection. If symptoms persist, other causes of hepatitis (e.g., Hepatitis A, B, or C) should be investigated.

Why It’s Important:

Hepatitis E is usually self-limiting, but in some cases, it can cause severe complications:

• Pregnancy: Can lead to life-threatening liver failure.
• Chronic liver disease: May worsen pre-existing conditions.
• Weakened immunity: Infection may be prolonged or more severe.