close button
Book Appointment
Returning user?  

Click here to login

Please select date*

Select Date and Time

Name*

Email*

Contact Number

No. of Attendee(s)*

1

Select Payment Method

Pay with Stripe if you are paying with a local or international card, or Select alternative payment methods

medex logo
  • PRICE SUMMARY
  • Selected Package
    0 THB
  • Full Price0 THB
    Discount0 THB
  • Final Priceincl. Taxes and Fees
    0 THB
By submitting this form, I acknowledge that I have read and agree to medex.co's Terms of Use and Privacy Policy.

Pay With

global pay icon
Medex logo
menu icon
Catalog
Logo

Our Services

close button
Book Appointment
Returning user?  

Click here to login

Please select date and time*

Select Date and Time

Name*

Email*

Contact Number

No. of Attendee(s)*

1

Select Payment Method

Pay with Stripe if you are paying with a local or international card, or Select alternative payment methods

medex logo

    • PRICE SUMMARY
    • Selected Package
      0 THB
    • Full Price0 THB
      Discount0
    • Final Priceincl. Taxes and Fees
      NaN THB
    By submitting this form, I acknowledge that I have read and agree to medex.co's Terms of Use and Privacy Policy.

    Pay With

    global pay icon

    Bence Jones Protein (BJP)

    Bence Jones Protein (BJP) refers to free immunoglobulin light chains (kappa or lambda) that are excreted in the urine

    Chhusya Bahal (Chhusya Galli), Jyatha, Thamel, Kathmandu 44600, Bagmati
    Instant Confirmation
    Verified
    Description

    Bence Jones Protein (BJP) refers to free immunoglobulin light chains (kappa or lambda) that are excreted in the urine. These proteins are produced by plasma cells, and their presence in the urine is often associated with certain hematologic disorders, particularly multiple myeloma.

    Description:

    • Structure: Bence Jones proteins are free light chains of immunoglobulins, either kappa or lambda, which are produced in excess due to clonal proliferation of plasma cells.
    • Solubility: They are unique in their thermal behavior—precipitating at 40–60°C and redissolving upon heating to higher temperatures (~100°C). This property was historically used to identify them.
    • Production: They are not typically bound to heavy chains (unlike intact immunoglobulins) and are small enough to pass through the renal glomeruli into urine.

    Clinical Uses of the Test:

    1. Diagnosis of Plasma Cell Disorders:
    • Multiple Myeloma: Bence Jones proteins are a hallmark of multiple myeloma, a cancer of plasma cells. Their presence in the urine strongly suggests this condition.
    • Waldenström's Macroglobulinemia: Can sometimes produce BJP due to excess monoclonal light chains.
    • Light Chain Deposition Disease (LCDD): BJP may indicate a related plasma cell disorder.
    1. Monitoring Disease Progression:
    • Quantifying Bence Jones protein levels can help assess disease burden in conditions like multiple myeloma or amyloidosis.
    1. Detecting Renal Involvement:
    • Excessive BJP can cause renal damage due to tubular toxicity, leading to "myeloma kidney" or cast nephropathy. Detection of BJP helps evaluate renal involvement.
    1. Assessment of Monoclonal Gammopathies:
    • Useful for identifying monoclonal light chains in monoclonal gammopathy of undetermined significance (MGUS), a precursor condition to multiple myeloma.

    Testing Methods:

    • Urine Protein Electrophoresis (UPEP): Used to detect and quantify Bence Jones proteins in the urine.
    • Immunofixation Electrophoresis (IFE): A highly sensitive method to confirm the presence of BJP and distinguish between kappa and lambda light chains.
    • Serum Free Light Chain Assay: While not a direct test for BJP, it complements urine studies by measuring free light chains in the blood.


    Arrow up
    Logo
    Bence Jones Protein (BJP)

    650 NPR