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    Beta-2 Glycoprotein IgG

    This test is primarily used in diagnosing and managing antiphospholipid syndrome (APS), a disorder characterized by thrombosis (blood clots) and pregnancy complications.

    Chhusya Bahal (Chhusya Galli), Jyatha, Thamel, Kathmandu 44600, Bagmati
    Instant Confirmation
    Verified
    Description

    Description:

    • Beta-2 Glycoprotein I (β2GP1):
    • A plasma protein primarily involved in inhibiting excessive clotting by binding to phospholipids on endothelial cells and platelets.
    • It also interacts with apoptotic cells, preventing unwanted immune responses.
    • Plays a critical role in maintaining the balance between clot formation and dissolution.
    • Autoantibodies:
    • In APS, the immune system produces IgG antibodies (and sometimes IgM/IgA) that target β2GP1.
    • These antibodies promote clot formation by interfering with β2GP1's anticoagulant functions and triggering inflammatory pathways.

    Uses of the Beta-2 Glycoprotein IgG Test:

    1. Diagnosis of Antiphospholipid Syndrome (APS):
    • The presence of β2GP1 IgG is one of the diagnostic criteria for APS when combined with clinical features such as:
    • Recurrent arterial or venous thrombosis.
    • Pregnancy complications (e.g., recurrent miscarriages, preeclampsia, or intrauterine growth restriction).
    • This test is often performed alongside:
    • Lupus Anticoagulant (LA)
    • Anticardiolipin Antibodies
    1. Thrombosis Risk Assessment:
    • Helps identify individuals at increased risk for blood clots (e.g., deep vein thrombosis, pulmonary embolism, or stroke).
    • Positive results, especially persistent over time, indicate higher thrombotic risk.
    1. Pregnancy Monitoring in APS:
    • Women with APS and positive β2GP1 IgG are at higher risk for complications such as miscarriage or preterm delivery.
    • Monitoring and management (e.g., anticoagulation therapy) are essential.
    1. Evaluation of Autoimmune Conditions:
    • β2GP1 IgG may also appear in patients with other autoimmune disorders such as systemic lupus erythematosus (SLE).

    Interpretation of Results:

    • Positive β2GP1 IgG:
    • Suggests an autoimmune process affecting coagulation, often in the context of APS.
    • Persistence of positive results 12 weeks apart is required for a definitive APS diagnosis.
    • Negative β2GP1 IgG:
    • Does not exclude APS, as some patients may have other antiphospholipid antibodies (e.g., anticardiolipin or lupus anticoagulant).


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    Beta-2 Glycoprotein IgG

    4,050 NPR