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      Beta-2 Glycoprotein IgG

      This test is primarily used in diagnosing and managing antiphospholipid syndrome (APS), a disorder characterized by thrombosis (blood clots) and pregnancy complications.

      Chhusya Bahal (Opposite of Kantipur Temple House), Jyatha, Thamel ║ 🚶Walk-in and 💵 Cash Payment at Counter Allowed ⏰ Open Daily from 7 AM to 9 PM 🔬 All Blood, Urine, Stool, and Swab Lab Tests Available 💊 In-Store and Online Pharmacy 👨‍⚕️ General and Travel Medicine Related Consultation 🇳🇵Located at the Heart of Kathmandu, Bagmati
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      Description

      Description:

      • Beta-2 Glycoprotein I (β2GP1):
      • A plasma protein primarily involved in inhibiting excessive clotting by binding to phospholipids on endothelial cells and platelets.
      • It also interacts with apoptotic cells, preventing unwanted immune responses.
      • Plays a critical role in maintaining the balance between clot formation and dissolution.
      • Autoantibodies:
      • In APS, the immune system produces IgG antibodies (and sometimes IgM/IgA) that target β2GP1.
      • These antibodies promote clot formation by interfering with β2GP1's anticoagulant functions and triggering inflammatory pathways.

      Uses of the Beta-2 Glycoprotein IgG Test:

      1. Diagnosis of Antiphospholipid Syndrome (APS):
      • The presence of β2GP1 IgG is one of the diagnostic criteria for APS when combined with clinical features such as:
      • Recurrent arterial or venous thrombosis.
      • Pregnancy complications (e.g., recurrent miscarriages, preeclampsia, or intrauterine growth restriction).
      • This test is often performed alongside:
      • Lupus Anticoagulant (LA)
      • Anticardiolipin Antibodies
      1. Thrombosis Risk Assessment:
      • Helps identify individuals at increased risk for blood clots (e.g., deep vein thrombosis, pulmonary embolism, or stroke).
      • Positive results, especially persistent over time, indicate higher thrombotic risk.
      1. Pregnancy Monitoring in APS:
      • Women with APS and positive β2GP1 IgG are at higher risk for complications such as miscarriage or preterm delivery.
      • Monitoring and management (e.g., anticoagulation therapy) are essential.
      1. Evaluation of Autoimmune Conditions:
      • β2GP1 IgG may also appear in patients with other autoimmune disorders such as systemic lupus erythematosus (SLE).

      Interpretation of Results:

      • Positive β2GP1 IgG:
      • Suggests an autoimmune process affecting coagulation, often in the context of APS.
      • Persistence of positive results 12 weeks apart is required for a definitive APS diagnosis.
      • Negative β2GP1 IgG:
      • Does not exclude APS, as some patients may have other antiphospholipid antibodies (e.g., anticardiolipin or lupus anticoagulant).


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      Beta-2 Glycoprotein IgG

      4,050 NPR

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