🩺 MPL W515/S505 Mutation Analysis at MedEx Neo Clinic, Kathmandu 📍 The MPL W515/S505 mutation analysis at MedEx Neo Clinic, Kathmandu focuses on detecting specific hotspot mutations (W515 and S505) in the MPL gene, which are strongly associated with myeloproliferative disorders including essential thrombocythemia and primary myelofibrosis. These mutations cause constitutive activation of the thrombopoietin receptor, leading to abnormal blood cell production. This molecular test uses targeted PCR and sequencing techniques for accurate mutation identification, aiding precise diagnosis and targeted treatment strategies.