Comprehensive Gut Microbiome Analysis and Personalized Health Solutions

The human gut is home to a vast and complex ecosystem of microorganisms that influence nearly every aspect of health. With over 50-100 trillion microbiota weighing approximately 2 kilograms (4.4 lbs) and outnumbering human cells by a ratio of 2:1, the gut microbiome plays a pivotal role in maintaining overall well-being. The Greenbiome GUT test offers a cutting-edge solution to assess the health of your gut microbiota and its impact on various health conditions, providing tailored recommendations to optimize your health.

Why the Balance of the Gut Microbiome is Crucial

Research shows that 90% of human diseases are linked to gut microbiota imbalances. A well-balanced microbiome supports:

• Immunity: Guards against harmful bacteria and pathogens.
• Digestion: Breaks down food, synthesizes vitamins, and supports nutrient absorption.
• Brain Health: Influences mood, behavior, and cognitive function.
• Disease Prevention: Reduces risks of obesity, diabetes, cardiovascular diseases, and more.

An imbalanced microbiome, on the other hand, can trigger inflammatory diseases, digestive issues, and metabolic disorders. Frequent intake of processed and high-fat foods, lack of fiber, and poor lifestyle choices are common contributors to microbiome imbalances.

Do You Have Symptoms of Gut Microbiome Imbalance?

Signs of an imbalanced gut may include:

• Digestive distress: Bloating, diarrhea, or constipation.
• Persistent inflammatory acne or recurring allergic rashes.
• Difficulty losing weight despite dietary efforts.
• Mental health challenges: Anxiety, depression, or migraines.
• Chronic fatigue, bad breath, and mucus in stools.

What is Greenbiome GUT?

The Greenbiome GUT test evaluates your gut microbiome’s health through a non-invasive stool sample. Using advanced Next Generation Sequencing (NGS), it screens microbiota associated with the following health conditions:

Conditions Linked to Gut Microbiota:

1. Obesity: Regulates inflammation and fat metabolism.
2. Irritable Bowel Syndrome (IBS): Identifies gut inflammation and infection risks.
3. Diabetes: Evaluates gut bacteria influencing insulin sensitivity and sugar metabolism.
4. Cholesterol and Cardiovascular Diseases: Examines microbiota involved in cholesterol regulation and meat-based diet risks.
5. Colon Polyps: Highlights inflammatory risks and early markers for colorectal cancer.
6. Depression: Links gut bacteria to mood-regulating neuroactive molecules.
7. Rheumatoid Arthritis: Tracks immune system imbalances.
8. Age-Related Macular Degeneration: Assesses vascular risks influenced by gut microbes.

Key Metrics Assessed by the Test

1. Gut Microbiota Balance

Evaluates the ratio of beneficial bacteria (e.g., Bifidobacterium, Lactobacillus) versus harmful bacteria (e.g., Proteobacteria, Clostridium). A balanced microbiota ensures reduced inflammation and a robust immune response.

2. Microbiota Diversity

Diversity indicates resilience. Higher diversity scores correlate with better disease resistance and metabolic function. Low diversity is linked to conditions like obesity, IBS, and diabetes.

3. Beneficial vs. Harmful Bacteria Ratio

A healthy gut microbiome is marked by a higher proportion of beneficial bacteria, which:

• Prevent gut inflammation.
• Enhance metabolic function.
• Protect against harmful pathogens.

4. Probiotic Deficiencies

The test identifies deficiencies in key probiotics like Lactobacillus and Bifidobacterium, essential for digestion, immunity, and mental health.

5. Enterotype Classification

Your microbiota is categorized into dietary-based types (e.g., Vegetarian, Meatarian, Omnivorous), offering insights into your gut’s dietary preferences and potential health risks.

How the Test Works

1. Specimen Collection: Collect a stool sample at home or in a hospital using a non-invasive swab (similar to ATK tests).
2. Sample Processing: The sample undergoes advanced NGS analysis at GC Genome Laboratory.
3. Results Timeline: Comprehensive results are delivered to your healthcare provider within 13 days.

Disease Risk Assessment and Scoring

The Greenbiome GUT test provides detailed risk scores (0-100) for the following conditions:

• Obesity: Analyzes microbes like Akkermansia muciniphila, which prevent fat accumulation and metabolic disorders.
• IBS: Identifies bacteria linked to gut inflammation, such as Bacteroides and Lactobacillus.
• Diabetes: Evaluates bacteria like Roseburia and Faecalibacterium that influence sugar metabolism and insulin sensitivity.
• Cholesterol: Highlights bacteria such as Eubacterium coprostanoligenes that reduce blood cholesterol levels.
• Depression: Links anti-inflammatory bacteria (e.g., Faecalibacterium) to mental health.
• Cardiovascular Diseases: Examines TMAO-producing bacteria influenced by high-meat diets.
• Colon Polyps and Cancer Risks: Tracks harmful bacteria like Fusobacterium nucleatum.

Practical Recommendations

1. Dietary Adjustments

• Increase:
• Fermented foods (e.g., yogurt, kimchi) to boost microbial diversity.
• High-fiber foods to feed beneficial bacteria.
• Foods rich in polyphenols and antioxidants like blueberries and green tea.
• Reduce:
• Processed meats, high-fat, sugary, or salty foods.
• Alcohol and spicy foods.

2. Probiotic and Prebiotic Supplements

Target deficiencies with personalized probiotic recommendations to:

• Restore beneficial bacteria.
• Prevent inflammation and disease risks.

3. Lifestyle Changes

• Sleep: 6–8 hours of consistent sleep reduces gut stress.
• Exercise: 30+ minutes of moderate activity 3–5 times per week promotes microbial diversity.

Preparing for the Test

• No fasting is required.
• Avoid antibiotics for 3 days prior to specimen collection.

Benefits of the Screening

• Early Detection: Identifies potential health risks before symptoms manifest.
• Tailored Health Strategy: Combines microbiota insights with dietary, lifestyle, and supplement recommendations.
• Comprehensive Analysis: Offers a detailed breakdown of over 100 microbial species linked to major health conditions.

Who Should Take This Test?

The Greenbiome GUT test is ideal for:

• Individuals experiencing digestive issues (e.g., bloating, diarrhea, constipation).
• Those with persistent skin problems, migraines, or chronic fatigue.
• People at risk for metabolic disorders like diabetes or obesity.
• Anyone seeking personalized dietary and lifestyle guidance.

Empowering Better Health Through Science

The Greenbiome GUT test bridges the gap between advanced microbiome research and practical health solutions. By understanding your unique gut microbiome, you can take control of your health with actionable insights, tailored recommendations, and preventative strategies. Whether you're addressing current symptoms or planning for long-term wellness, the Greenbiome GUT test provides the roadmap to a healthier you.