Hereditary risk screening cancer panels target genes previously linked to a predisposition of cancer. Panel selection was based on expert curation of scientific literature and other high-quality resources, including formal medical guidelines.

DETAILS
Screens for 74 genes
• ALK, APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDC73, CDH1, CDK12, CDK4, CDKN1B, CDKN2A, CHEK2, EPCAM, EXT1, EXT2, FANCG, FH, FLCN, GALNT12, KIT, MAX, MEN1, MET, MLH1, MLH3, MRE11A, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NTHL1, NTRK1, PALB2, PDGFRA, PHOX2B, PMS1, PMS2, POLD1, POLE, PRSS1, PTCH1, PTCH2, PTEN, RAD50, RAD51C, RAD51D, RB1, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SPINK1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, WT1, XPC

23 Cancer types
• Breast, Ovarian, Colorectal, Gastric, Kidney, Multiple endocrine adenoma, Thyroid, Parathyroid, Multiple neurofibromatosis, Pheochromocytoma, Bladder, Urothelial carcinoma, Familial paraganglioma, Retinoblastoma, Melanoma, Multiple osteochondroma, Pancreatic, Endometrial, Gastrointestinal stromal tumors, Familial neuroblastoma, Tuberous sclerosis, Nevus basal cell carcinoma, Familial nephroblastoma.

DESCRIPTION
Test Time, Result Turnaround, Email Delivery
• The approximate service time for this package is 10-20 minutes.
• The package is available for women and men.
• Test results are typically available within 26 business days and will be delivered via email.
• Blood sample will be collected for 3 cc.
• There is no need to withhold water and food prior to the blood drawn.

General Information
Individuals with a family history of cancer may have an increased risk of cancer if they have inherited a cancer-causing mutation. The SENTIS Hereditary cancer Screening analyzes germline mutation across 74 genes that are associated with 23 types of hereditary cancer, including some of the most commonly occurring cancers such as hereditary breast, ovarian, colorectal, prostate and stomach cancer. Identification of cancer-causing mutations can help confirm a diagnosis, guide treatment and health management decision or guide further testing of at-risk relatives.

Advantages
• Comprehensive Whole exome plus flanking intronic regions covered for all genes tested; one single assay that detects point mutations, deletions, insertions, duplications, rearrangement.
(Alterations in methylation and complex genomic aberrations such as uniparental disomy, balanced translocation, inversion, ploidy changes, duplication and deletion of large DNA fragments and/or other rare alternations are not included. Also, there are some regions that cannot be fully covered)
• Robust Clinically important (pathogenic or likely pathogenic) variants are verified by Sanger sequencing while large gene rearrangements are verified by qPCR.
• Convenient Test from peripheral blood or DNA
• Professional State-of-the-art variant database ensures up-to-date analysis and interpretation. We also have a dedicated genetic counselling team offering professional genetic counselling services.