Hereditary risk screening cancer panels target genes previously linked to a predisposition of cancer. Panel selection was based on expert curation of scientific literature and other high-quality resources, including formal medical guidelines.

DETAILS
Screens for 26 genes
• BRCA1, BRCA2, CHEK2, PALB2, BRIP1, TP53, PTEN, STK11, CDH1, ATM, BARD1, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, PMS1, PMS2, RAD50, RAD51C, RAD51D, NF1, EPCAM, SMARCA4, CDK12
DESCRIPTION
Test Time, Result Turnaround, Email Delivery
• The approximate service time for this package is 10-20 minutes.
• The package is available for women and men.
• Test results are typically available within 26 business days and will be delivered via email.
• Blood sample will be collected for 3 cc.
• There is no need to withhold water and food prior to the blood drawn.

General Information
Germline mutations in BRCA1 and BRCA2 genes have been associated with an increased risk of breast and ovarian cancer. Approximately 25% of hereditary breast cancer cases are caused by BRCA1 and BRCA2 mutations, and around 10% of all breast cancers. Mutations in BRCA1 and BRCA2 account for around 15% of ovarian cancers overall. With BGI’s SENTIS BRCA test, you can be assured that no pathogenic variant will be missed. BGI provides targeted and affordable BRCA1 and BRCA2 testing and also offers an extended 26-gene panel that analyzes other relevant genes for mutation that could also increase the risk of breast and ovarian cancer, as recommended by medical guidelines.

Advantages
• Comprehensive Whole exome plus flanking intronic regions covered for all genes tested; one single assay that detects point mutations, deletions, insertions, duplications, rearrangement.
(Alterations in methylation and complex genomic aberrations such as uniparental disomy, balanced translocation, inversion, ploidy changes, duplication and deletion of large DNA fragments and/or other rare alternations are not included. Also, there are some regions that cannot be fully covered)
• Robust Clinically important (pathogenic or likely pathogenic) variants are verified by Sanger sequencing while large gene rearrangements are verified by qPCR.
• Convenient Test from peripheral blood or DNA
• Professional State-of-the-art variant database ensures up-to-date analysis and interpretation. We also have a dedicated genetic counselling team offering professional genetic counselling services.